Summary:Fluoxastrobin is a green strobilurin fungicide made by German Giant Bayer Crop science AG. it has been authorized to Japan company Arysta Life Science in the world for Fluoxastrobin sales and marketing since 2005. Fluoxastrobin has bright market prospects with the expiry of its patent worldwide.?
Fluoxastrobin, a new versatile type of foliar fungicides, is a novel broad-spectrum strobilurin fungicide from the chemical class of dihydro-dioxazines, and has demonstrated excellent plant health properties.
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The commodity name of fluoxastrobin is Fandango. fluoxastrobin ?is the active ingredient in the two brand families-DISARM and EVITO fungicides of Arysta LifeScience. ?The chemical structure of fluoxastrobin is as below:

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Fluoxastrobin physical properties
The main starting materials to fluoxastrobin synthesis ?are 2- diethyl fluoromalonate and 2-Hydroxyphenylacetic acid methyl ester. The chemical name of fluoxastrobin is 2 - {[6- (2-chlorophenoxy) -5-fluoropyrimidin-4-yl] oxy} phenyl) (5,6- dihydro-1,4,2-dioxazin-3-yl) methanone. High quality Fluoxastrobin 99% is in a white crystalline form with melting point at 75 ?? The general CAS number of fluoxastrobin is 361377-29-9 (E-isomer). While sometimes some seldom companies use 193740-76-0. According to our experts, dimethyl fluoromalonate is a better choice for synthesizing fluoxastrobin.
Fluoxastrobin development process
In 1994, Bayer CropScience synthesized fluoxastrobin and apply it to crop and non-crop areas. At the very beginning, Europe and North America were the primary target markets.
At the beginning of 2004, Bayer fluoxastrobin obtain registration in UK, registration of the main crops include crop grain, especially for a variety of diseases on wheat and barley and broad-spectrum activity. To take all disease (take-al1), sharp eye spot, rust, wheat glume blight, net blotch disease has a good control activity. For the first time fluoxastrobin -containing azoxystrobin tradename is Fandango, compounded by fluoxastrobin and prothioconazole.
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In 2005, the Japanese company Arysta Life Sciences Bayer obtained fluoxastrobin worldwide sales distribution rights, but limited to non crop areas such as lawns and ornamental crops.
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In 2012, Ailisida signed an agreement with Bayer again, Arysta gets fluoxastrobin in crop and non-crop areas of the two exclusive marketing rights, while Bayer retains a fluoxastrobin seed treatment as well as some development and marketing rights of the private complex products. After a series of marketing authorization and collaboration with Bayer, in 2012, Arysta has been successfully put two brands Evito and Disarm to the markets, which Evito for fruit and vegetables, Disarm for lawn.
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In 2013, Arysta reached an agreement with Italian agrochemical company ?Isagro S.P.A ?for joint development and marketing of fluoxastrobin and tetrafluoroethylene difenoconazole fungicide; In the same year, Arysta and Cheminova cooperated and launched Fortix in the United States, for corn and soybeans.
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In 2014, American FMC Corporation won the arysta authorization of Disarm series products in the United States in the fields of turf and ornamental crops.?
Fluoxastrobin toxicity
Rat acute oral LD50>2500mg/kg body weight, acute percutaneous LD50>2000MG/KG. Irritation Rabbit eye,No stimulation of the skin of the rabbit, the guinea pig skin It has no sensitive effect on the rat did not find embryonic toxicity, reproductive toxicity and the role of the non carcinogenic effects and neurotoxicity.
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On 24 October, the United States Environmental Protection Agency (EPA) published a final rule on the tolerances for combined residues of fluoxastrobin. This regulation establishes tolerances for combined residues of fluoxastrobin and it? Z-isomer in or on poultry, liver; hog, fat; hog, meat byproducts; and rice, grain. Arysta LifeScience, North America, LLC, requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA). This regulation is effective from 24 October 2012.
Fluoxastrobin Mechanism
As a strobilurin fungicide family member, fluoxastrobin works as an inhibitor of mitochondrial respiration, by inhibiting electron transfer between cytochrome b and C1. Fluoxastrobin, as a new fungicide with protective and therapeutic function, has the dual characteristics of contacting and persisting effect. Mitochondria outside cell nucleus provides the nucleus of the main cellular energy (ATP) through respiration嚗f mitochondrial respiration blocked, and can not produce ATP, the cell will die. Many fungicides work on mitochondrial respiration, but the working part ?(cytochrome b) of strobilurin compound ?are all different from those conventional fungicides, and therefore sells well as inhibitors of sterol, phenyl amides, and dicarboxylic amides benzimidazole resistant strains.
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Fluoxastrobin is mainly used for foliage treatment, an application rate of 75 ~ 200 g a.i./hm2; it is also used as a seed treatment, in an amount of 5 ~ 10 g / 100 kg of seed. Although absorption ability of fluoxastrobin by seed and root is poor, when used as a seed treatment, seedlings of seed-borne and soil-borne diseases have a good role in the killing and holding effect.
Fluoxastrobin Applications
Field experiments showed that fluoxastrobin meets or exceeds the best varieties of azoxystrobin currently on the market for the ?disease control of wheat leaf blight, Ying blight and rust, barley moire disease, stripe rust,etc.
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Fluoxastrobin has wide bactericidal spectrum, for almost all fungal classes (Ascomycetes, basidiomycetes, egg bacteria and fungi imperfecti) disease such as rust, glume blight, net blotch, powdery mildew, blight, downy mildew and a total eclipse of the disease had good activity for cereal crops, soybean, cotton, coffee, citrus fruits, peanuts, potatoes, vegetables, ornamental plants and turf etc.
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fluoxastrobin application scope is wide, both in the early fungal infection such as spore germination, germ tube growth and invasion of leaf, and in hyphal growth period. Fluoxastrobin provides very good role in the protection and treatment; and ?the most effective in ?the spore germination and at the early stage of infection. Because of its excellent internal absorption activity, fluoxastrobin can be quickly absorbed, and can be transferred to the top of the leaf evenly, thus has a good resistance to water erosion.
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Fluoxastrobin is suitable for crops and safety of cereal crops, potatoes, vegetables and coffee, under the recommended dose of the crop safety, groundwater, environmental safety.
Global fluoxastrobin products

Fandango
Fluoxastrobin10% + 10% prothioconazole
Bayer

Scenic
Fluoxastrobin3.75%+3.75%prothioconazole, tebuconazole + 0.5%
Bayer

Redigo Twin
Fluoxastrobin3.75%+ 3.75% prothioconazole
Bayer

EFA
Fluoxastrobin + prothioconazole + tebuconazole + prazosin
Bayer

Vigold 480 SC
48% fluoxastrobin
Bayer

Fluoxastrobin ST
41.4% fluoxastrobin
Bayer

Disarm C
Fluoxastrobin 2.44% + 38.4% chlorothalonil
Arysta

Disarm G
0.25% fluoxastrobin
Arysta

Disarm M
15.81% fluoxastrobin + 25.6% myclobutanil
Arysta

Disarm M Granular
Fluoxastrobin 0.25% + 0.43% myclobutanil
Arysta

Evito 480 SC
40.3% fluoxastrobin
Arysta

Evito T
18% fluoxastrobin + tebuconazole 25%
Arysta

Fortix
14.84% fluoxastrobin + 19.3% flutriafol
Arysta, Cheminova

Zolera FX
Fluoxastrobin 17.76% + 17.76% tebuconazole
Arysta

Fluoxastrobin Patent
January 14, 2017, fluoxastrobin in China, Europe and the world patents expire; January 15, 2017, the expiration of its patent in the United States.?
September 19, 2015, fluoxastrobin expiry of the registration data protection in the United States; its registration data protection in the EU until July 31, 2018.
Fluoxastrobin market
According to statistics, in 2013 global sales of strobilurin fungicides is $ 3.324 billion, accounting for 21.2% of the total world market sales of fungicides, pesticides 5.5 percent of the total world market sales. Under the multinational co-cultivation led by Arysta and Bayer , fluoxastrobin sales is rising year by year. In 2013,fluoxastrobin global sales is $ 171 million, accounting for 5.1% of the total strobilurin fungicide sales. It is predicted that in the next five years fluoxastrobin remain at an average annual growth rate of 5.9%. Strobilurin fungicide has become another class of triazole fungicides after the great development potential and market viability of new agricultural fungicides.?
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Azoxystrobin global sales is up to $ 1.165 billion in 2013, while fluoxastrobin only $ 171 million, mainly due to the market promotion of Syngenta in soybean field. However, in recent years, due to generic competition, ?azoxystrobin products sales began to show a downward trend. The reducing market share azoxystrobin will bring development opportunities to other strobilurin fungicides. On azoxystrobin served cereals sector, fluoxastrobin have a stronger advantage. Field tests showed that fluoxastrobin met or exceeded azoxystrobinin the control of wheat leaf spot disease, glume blight and rust, barley blotch, stripe disease, rust and powdery mildew, and fluoxastrobin has a larger space for development in the coming future.
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With fluoxastrobin constantly expire worldwide, there will be more companies to consider pesticide products apply fluoxastrobin to their product lines.