This site uses cookies to provide you with a better experience. For information on our Privacy and Cookie Policy, please visit this page. By continuing to use the site or closing this banner, you are agreeing to our terms of use. Close

Market Research Analysis Report for intermediate D-p-Methyl?sulfone?phenyl?ethyl?serinate

2017/02/15
  • LINE
  • X
  • LinkedIn

Introduction to D-p-Methyl?sulfone?phenyl?ethyl?serinate
D-p-Methyl?sulfone?phenyl?ethyl?serinate, in scientific articles,literatures, the name D-threo?form of?p-methylsulfonylphenyl serine ethyl ester (MPSE) is more often used.In this sense, we will use D-threo-p-MPSE for short. It is a pharmaceutical intermediate, mainly applied in producing veterinary antibiotics such as Florfenicol and Thiamphenicol. D-p-Methyl?sulfone?phenyl?ethyl?serinate (D-ethyl ester) is the core product of Banff Green Technologies, Inc. The annual production capacity is 2000 MT. Banff Green Technologies, Inc. owns the most advantaged technologies in the world. Florfenicol and Thiamphenicol manufacturers are welcome to send us inquiries.

Physical properties of D-p-Methyl?sulfone?phenyl?ethyl?serinate
Product name: D-p-Methyl?sulfone?phenyl?ethyl?serinate
Synonym: D-threo-p-MPSE
CAS No.?嚗?6983-12-7
The molecular formula of D-threo-p-MPSE ester is C12H17NO5S, and its molecular weight is 287.33. D-ethyl ester appears in the form of white or off-white crystalline powder. Its density is 1.309g/cm3, and the melting point is 129-132?? D-ethyl ester is slightly soluble in water. It is soluble in organic solvent. D-ethyl ester is the important intermediate for synthesizing the API Thiamphenicol and the veterinary drug Florfenicol. Presently there is no national or industry quality standard for D-threo-p-MPSE. Manufacturer's standard applies.
Certificates of analysis(COA) for D-p-Methyl?sulfone?phenyl?ethyl?serinate
Application of D-p-Methyl?sulfone?phenyl?ethyl?serinate
D-p-Methyl?sulfone?phenyl?ethyl?serinate is a pharmaceutical intermediate mainly for Florfenicol and Thiamphenicol .
Florfenico1? trade name is Nuflor. It is a new type of fluorinated synthetic analog of thiamphenicol for?veterinary?use developed by Schering?lough in 1988. It is characterized for low toxicity, no residu, no tolerance, broad antimicrobial spectrum, good absorption, broad spread in body, safe, high effectiveness, and so on. It is especially efficient for bacterial diseases caused by sensitive bacteria in poultry and enjoys high reputation in the global animal healthcare market.
As for Thiamphenicol, its methyl sulfone replaces the nitryl in chloramphenicol and therefore its toxicity is much lower than chloramphenicol. Meanwhile, its internal antibacterial effect is 2.5 time of chloramphenicol. As a result, Thiamphenicol has become the urgent need for both the users and the developing market.
D-p-Methyl?sulfone?phenyl?ethyl?serinate VS Florfenicol
Currently, there are mainly 2 industrialized manufacture methods for producing Florfenicol:
1, Reduce D-p-Methyl?sulfone?phenyl?ethyl?serinate and react it with benzonitrile, getting oxazolone therefrom. Add Ishikawa for fluoridation, hydrolysis reaction, and 2-chloride acetylation and get Florfenicol.
2, Reduce D-p-Methyl?sulfone?phenyl?ethyl?serinate and react it with Dichloroacetonitrile, getting oxazolone therefrom. Add Ishikawa for fluoridation and hydrolysis reaction and get Florfenicol.
The second method saves the 2-chloride acetylation and effectively reduces the production steps and cost.

No matter which method, the starting raw material is D-p-Methyl?sulfone?phenyl?ethyl?serinate. The D-p-Methyl?sulfone?phenyl?ethyl?serinate manufactured by Banff Green Technologies, Inc. is specified >99%. It is qualified for export and very reliable.
D-p-Methyl?sulfone?phenyl?ethyl?serinate VS Thiamphenicol
So far there is few documents of synthesizing Thiamphenicol from D-p-Methyl?sulfone?phenyl?ethyl?serinate. Basicly, resolve D-p-Methyl?sulfone?phenyl?ethyl?serinate in methanol. Add sodium borohydride and methyl dichloroacetate for reactions, heating, stiring, filtering, freezing, washing, etc. Banff Green Technologies, Inc. applies more advanced technologies to produce Thiamphenicol, effectively reducing the cost. More importantly, it is environment-friendly and is suitable for bulk production.
Should you need detailed information for the ROS, synthesis index, technical formula, and process equipment, please kindly contact us directly.
Main raw material for producing D-p-Methyl?sulfone?phenyl?ethyl?serinate
The main materials for producing D-p-Methyl?sulfone?phenyl?ethyl?serinate include: P benzaldehyde, cupric sulfate, glycine, ethanol, D-Tartaric acid, sulphuric acid, NaOH, aqua ammonia, etc. The most important raw material is P benzaldehyde, with the largest consumption.
Research on production process of D-p-Methyl?sulfone?phenyl?ethyl?serinate
There are 2 routes of synthesis for producing D-p-Methyl?sulfone?phenyl?ethyl?serinate: route of D-4-Methylsulfonylphenyl serine and route of D-4-Methylsulfonylphenyl serine nantokite.
Route of D-4-Methylsulfonylphenyl serine: directly esterify D-4-Methylsulfonylphenyl serine with ethanol. However, the yield of esterification is as low as 65-70%. It consumes a large quantity of concentrated sulfuric acid. The waste acid in the mother liquid is hard to handle. What? more, the yield of resolution is only 70%, and the total yield is lower than 50%.
Route of D-4-Methylsulfonylphenyl serine nantokite: react glycine, cupric sulfate, and P benzaldehyde under alkaline conditions and get D-4-Methylsulfonylphenyl serine nantokite. Esterify it with ethanol with the catalysis of sulphuric acid. There is no Red structure generated from the esterification. The by-product is cupric sulfate, and the mother liquid can be applied repeatedly. The aftertreatment is simple and the cost is low. The yield of esterification, yield of resolution, and the total yield are high. Thus, this route excels the route of D-4-Methylsulfonylphenyl serine.
Accordingly, most manufacturers in China produce D-p-Methyl?sulfone?phenyl?ethyl?serinate with the route of D-4-Methylsulfonylphenyl serine nantokite. The production process is consist of nantokite synthesis, esterification, and chiral resolution.
The production process of Banff Green Technologies, Inc. prevails in the industry. We adopt a series of clean production measures in the production process. The raw materials, energy consumption, technological process, equipments, and the comprehensive utilization of waste have all reached the leading role around the world.
Process of flowsheet of D-p-Methyl?sulfone?phenyl?ethyl?serinate
The D-p-Methyl?sulfone?phenyl?ethyl?serinate project applies the Route of D-4-Methylsulfonylphenyl serine nantokite. Firstly, synthesize nantokite through complexation, and then synthesize 3-(4-(METHYLSULFONYL)PHENYL)SERINE ETHYL ESTER sulphate through esterification. Get DL-p-Methyl?sulfone?phenyl?ethyl?serinate through extraction of ammonia. Resolve DL-p-Methyl?sulfone?phenyl?ethyl?serinate and synthesize D- ethyl tartrate. Extract it with ammonia and get D-p-Methyl?sulfone?phenyl?ethyl?serinate.
Manufacturers of D-p-Methyl?sulfone?phenyl?ethyl?serinate
Banff Green Technologies, Inc. is a professional manufacturer of D-p-Methyl?sulfone?phenyl?ethyl?serinate in China. The annual production capacity is 2000 MT. There is a large stock available. Our production process is advanced and the emission index have all reached the national standards.
Banff green technologies, inc. Is a technologically innovative company that focuses on chemicals, materials, pharmaceuticals, crop science and environmental technology. The company headquarter is based in shanghai, china. Our research and development team is comprised of a talented and experienced team of PhD? with strong scientific backgrounds dedicated to our mission. We are also supported by strong infrastructure, which include state of the art lab facilities, two pilot facilities and seven manufacturing sites located in five provinces in china.
Our corporate mission is to achieve environmental protection and sustainability while being socially responsible through our research and innovation. We sincerely hope to better serve our customers through every facets of their needs and together we can achieve a more sustainable future.

The market size of D-p-Methyl?sulfone?phenyl?ethyl?serinate
The market size of D-p-Methyl?sulfone?phenyl?ethyl?serinate is closely related to the market sizes of Florfenicol and Thiamphenicol. In 2015, the export volume of Florfenicol from China is 2199 MT, with 2000-3000 MT in the domestic market. The total market size is 5000-6000 MT, and it is continuously increasing in high speed. Consider that 1 MT of Florfenicol is produced with 1 MT of D-p-Methyl?sulfone?phenyl?ethyl?serinate, the global need for D-p-Methyl?sulfone?phenyl?ethyl?serinate is 5000-6000 MT. The vast need for Florfenicol requires the same need for D-p-Methyl?sulfone?phenyl?ethyl?serinate.
In the future, China will be the largest market of Florfenicol in the world. This is because as an agricultural country with 1.3 billion people, China has developed into the largest country of livestock breeding, feed processing and meat production. Our poultry, livestock, and aquatic product breeding industries are increasing fast. The quantities of our chicken and duck eggs, meat-type ducks, freshwater fish, and silkworms list top 1 in the world. It is supposed that our total yield of meat will be 90 million MT in 2020, and the yield of eggs will be 35 million MT. The huge livestock breeding market will provide tremendous developing room for D-p-Methyl?sulfone?phenyl?ethyl?serinate, intermediate for Florfenicol.
Banff Green Technologies, Inc. is the most professional manufacturer of D-p-Methyl?sulfone?phenyl?ethyl?serinate in China. Our annual production capacity is 2000 MT. We own the most advanced production technologies, the most environment-friendly production process, and fully automatic production equipment, providing D-p-Methyl?sulfone?phenyl?ethyl?serinate of the highest quality to China and the world. You are welcome to contact us for cooperation!

Recommendations For You

Browse Alphabetically : 0-9  A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z  Hot Searches
History
    Inquiry Cart